PKG Substrate ( —— )

产品货号. M30485 CAS No. 81187-14-6

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥2297	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

PKG Substrate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
产品描述

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM). (In Vitro):Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG.
体外实验

Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

PKG
研究领域

——
适应症

——

化学信息

CAS Number

81187-14-6
分子量

902.01
分子式

C35H67N17O11
纯度

>98% (HPLC)
溶解度

In Vitro:?H2O : 100 mg/mL (110.86 mM)
SMILES

——
化学全称

Sequence:Arg-Lys-Arg-Ser-Arg-Ala-Glu

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8.

计算器

浓度计算器

摩尔计算器

分子量计算器

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